Photobiomodulation preserves behaviour and midbrain dopaminergic cells from MPTP toxicity: evidence from two mouse strains
Identifieur interne : 004550 ( Main/Exploration ); précédent : 004549; suivant : 004551Photobiomodulation preserves behaviour and midbrain dopaminergic cells from MPTP toxicity: evidence from two mouse strains
Auteurs : Cécile Moro [France] ; Napoleon Torres [France] ; Nabil El Massri [Australie] ; David Ratel [France] ; Daniel M. Johnstone [Australie] ; Jonathan Stone [Australie] ; John Mitrofanis [Australie] ; Alim-Louis Benabid [France]Source :
- BMC Neuroscience [ 1471-2202 ] ; 2013.
Abstract
We have shown previously that near-infrared light (NIr) treatment or photobiomodulation neuroprotects dopaminergic cells in substantia nigra pars compacta (SNc) from degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Balb/c albino mice, a well-known model for Parkinson’s disease. The present study explores whether NIr treatment offers neuroprotection to these cells in C57BL/6 pigmented mice. In addition, we examine whether NIr influences behavioural activity in both strains after MPTP treatment. We tested for various locomotive parameters in an open-field test, namely velocity, high mobility and immobility.
Balb/c (albino) and C57BL/6 (pigmented) mice received injections of MPTP (total of 50 mg/kg) or saline and NIr treatments (or not) over 48 hours. After each injection and/or NIr treatment, the locomotor activity of the mice was tested. After six days survival, brains were processed for TH (tyrosine hydroxylase) immunochemistry and the number of TH+ cells in the substantia nigra pars compacta (SNc) was estimated using stereology. Results showed higher numbers of TH+ cells in the MPTP-NIr groups of both strains, compared to the MPTP groups, with the protection greater in the Balb/c mice (30% vs 20%). The behavioural tests revealed strain differences also. For Balb/c mice, the MPTP-NIr group showed greater preservation of locomotor activity than the MPTP group. Behavioural preservation was less evident in the C57BL/6 strain however, with little effect of NIr being recorded in the MPTP-treated cases of this strain. Finally, there were differences between the two strains in terms of NIr penetration across the skin and fur. Our measurements indicated that NIr penetration was considerably less in the pigmented C57BL/6, compared to the albino Balb/c mice.
In summary, our results revealed the neuroprotective benefits of NIr treatment after parkinsonian insult at both cellular and behavioural levels and suggest that Balb/c strain, due to greater penetration of NIr through skin and fur, provides a clearer model of protection than the C57BL/6 strain.
Url:
DOI: 10.1186/1471-2202-14-40
PubMed: 23531041
PubMed Central: 3616839
Affiliations:
- Australie, France
- Auvergne-Rhône-Alpes, Nouvelle-Galles du Sud, Rhône-Alpes
- Sydney
- Université de Sydney
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Johnstone</name><affiliation wicri:level="4"><nlm:aff id="I3">Department of Physiology, University of Sydney, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Physiology, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Stone, Jonathan" sort="Stone, Jonathan" uniqKey="Stone J" first="Jonathan" last="Stone">Jonathan Stone</name><affiliation wicri:level="4"><nlm:aff id="I3">Department of Physiology, University of Sydney, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Physiology, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name><affiliation wicri:level="4"><nlm:aff id="I2">Department of Anatomy & Histology, University of Sydney, Sydney, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Anatomy & Histology, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><affiliation wicri:level="1"><nlm:aff id="I1">CEA, LETI, CLINATEC, Grenoble, 38054, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CEA, LETI, CLINATEC, Grenoble, 38054</wicri:regionArea><wicri:noRegion>38054</wicri:noRegion><wicri:noRegion>38054</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Neuroscience</title><idno type="eISSN">1471-2202</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>We have shown previously that near-infrared light (NIr) treatment or photobiomodulation neuroprotects dopaminergic cells in substantia nigra pars compacta (SNc) from degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in Balb/c albino mice, a well-known model for Parkinson’s disease. The present study explores whether NIr treatment offers neuroprotection to these cells in C57BL/6 pigmented mice. In addition, we examine whether NIr influences behavioural activity in both strains after MPTP treatment. We tested for various locomotive parameters in an open-field test, namely velocity, high mobility and immobility.</p></sec><sec><title>Results</title><p>Balb/c (albino) and C57BL/6 (pigmented) mice received injections of MPTP (total of 50 mg/kg) or saline and NIr treatments (or not) over 48 hours. After each injection and/or NIr treatment, the locomotor activity of the mice was tested. After six days survival, brains were processed for TH (tyrosine hydroxylase) immunochemistry and the number of TH<sup>+</sup> cells in the substantia nigra pars compacta (SNc) was estimated using stereology. Results showed higher numbers of TH<sup>+</sup> cells in the MPTP-NIr groups of both strains, compared to the MPTP groups, with the protection greater in the Balb/c mice (30% vs 20%). The behavioural tests revealed strain differences also. For Balb/c mice, the MPTP-NIr group showed greater preservation of locomotor activity than the MPTP group. Behavioural preservation was less evident in the C57BL/6 strain however, with little effect of NIr being recorded in the MPTP-treated cases of this strain. Finally, there were differences between the two strains in terms of NIr penetration across the skin and fur. Our measurements indicated that NIr penetration was considerably less in the pigmented C57BL/6, compared to the albino Balb/c mice.</p></sec><sec><title>Conclusions</title><p>In summary, our results revealed the neuroprotective benefits of NIr treatment after parkinsonian insult at both cellular and behavioural levels and suggest that Balb/c strain, due to greater penetration of NIr through skin and fur, provides a clearer model of protection than the C57BL/6 strain.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Blandini, F" uniqKey="Blandini F">F Blandini</name></author><author><name sortKey="Nappi, G" uniqKey="Nappi G">G Nappi</name></author><author><name sortKey="Tassorelli, C" uniqKey="Tassorelli C">C Tassorelli</name></author><author><name sortKey="Martignoni, E" uniqKey="Martignoni E">E Martignoni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bergman, H" uniqKey="Bergman H">H 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sortKey="Riachi, Nj" uniqKey="Riachi N">NJ Riachi</name></author><author><name sortKey="Behmand, Ra" uniqKey="Behmand R">RA Behmand</name></author><author><name sortKey="Harik, Si" uniqKey="Harik S">SI Harik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schober, A" uniqKey="Schober A">A Schober</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bove, J" uniqKey="Bove J">J Bové</name></author><author><name sortKey="Perier, C" uniqKey="Perier C">C Perier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Piallat, B" uniqKey="Piallat B">B Piallat</name></author><author><name sortKey="Benazzouz, A" uniqKey="Benazzouz A">A Benazzouz</name></author><author><name sortKey="Benabid, Al" uniqKey="Benabid A">AL Benabid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wallace, Ba" uniqKey="Wallace B">BA Wallace</name></author><author><name sortKey="Ashkan, K" uniqKey="Ashkan K">K Ashkan</name></author><author><name sortKey="Heise, Ce" uniqKey="Heise C">CE Heise</name></author><author><name sortKey="Foote, Kd" uniqKey="Foote K">KD Foote</name></author><author><name sortKey="Torres, N" uniqKey="Torres N">N Torres</name></author><author><name sortKey="Mitrofanis, J" uniqKey="Mitrofanis J">J Mitrofanis</name></author><author><name sortKey="Benabid, Al" uniqKey="Benabid A">AL Benabid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luquin, N" uniqKey="Luquin N">N Luquin</name></author><author><name sortKey="Mitrofanis, J" uniqKey="Mitrofanis J">J Mitrofanis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bjorklund, A" uniqKey="Bjorklund A">A Björklund</name></author><author><name sortKey="Rosenblad, C" uniqKey="Rosenblad C">C Rosenblad</name></author><author><name sortKey="Winkler, C" uniqKey="Winkler C">C Winkler</name></author><author><name sortKey="Kirik, D" uniqKey="Kirik D">D Kirik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huot, P" uniqKey="Huot P">P Huot</name></author><author><name sortKey="Levesque, M" uniqKey="Levesque M">M Lévesque</name></author><author><name sortKey="Parent, A" uniqKey="Parent A">A Parent</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paxinos, G" uniqKey="Paxinos G">G Paxinos</name></author><author><name sortKey="Franklin, Bj" uniqKey="Franklin B">BJ Franklin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bezard, E" uniqKey="Bezard E">E Bezard</name></author><author><name sortKey="Dovero, S" uniqKey="Dovero S">S Dovero</name></author><author><name sortKey="Bioulac, B" uniqKey="Bioulac B">B Bioulac</name></author><author><name sortKey="Gross, C" uniqKey="Gross C">C Gross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldberg, Nr" uniqKey="Goldberg N">NR Goldberg</name></author><author><name sortKey="Haack, Ak" uniqKey="Haack A">AK Haack</name></author><author><name sortKey="Lim, Ns" uniqKey="Lim N">NS Lim</name></author><author><name sortKey="Janson, Ok" uniqKey="Janson O">OK Janson</name></author><author><name sortKey="Meshul, Ck" uniqKey="Meshul C">CK Meshul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meredith, P" uniqKey="Meredith P">P Meredith</name></author><author><name sortKey="Powell, Bj" uniqKey="Powell B">BJ Powell</name></author><author><name sortKey="Riesz, J" uniqKey="Riesz J">J Riesz</name></author><author><name sortKey="Nighswander Rempel, S" uniqKey="Nighswander Rempel S">S Nighswander-Rempel</name></author><author><name sortKey="Pederson, Mr" uniqKey="Pederson M">MR Pederson</name></author><author><name sortKey="Moore, E" uniqKey="Moore E">E Moore</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Nouvelle-Galles du Sud</li><li>Rhône-Alpes</li></region><settlement><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Moro, Cecile" sort="Moro, Cecile" uniqKey="Moro C" first="Cécile" last="Moro">Cécile Moro</name></region><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name><name sortKey="Ratel, David" sort="Ratel, David" uniqKey="Ratel D" first="David" last="Ratel">David Ratel</name><name sortKey="Torres, Napoleon" sort="Torres, Napoleon" uniqKey="Torres N" first="Napoleon" last="Torres">Napoleon Torres</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="El Massri, Nabil" sort="El Massri, Nabil" uniqKey="El Massri N" first="Nabil" last="El Massri">Nabil El Massri</name></region><name sortKey="Johnstone, Daniel M" sort="Johnstone, Daniel M" uniqKey="Johnstone D" first="Daniel M" last="Johnstone">Daniel M. Johnstone</name><name sortKey="Mitrofanis, John" sort="Mitrofanis, John" uniqKey="Mitrofanis J" first="John" last="Mitrofanis">John Mitrofanis</name><name sortKey="Stone, Jonathan" sort="Stone, Jonathan" uniqKey="Stone J" first="Jonathan" last="Stone">Jonathan Stone</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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